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Inhibition of this isoenzymeby erythromycin, clarithromycin, ketoconazole, itraconazoleis responsible for the important drug interaction withterfenadine, astemizole and cisapride (see p. [60] reported that in 70 children with osteoarticular infection(60% septic arthritis), an initial regimen of IV antibiotic(s) for 7 days, followed by 3 to5 weeks of oral therapy, was sufficient for cure.

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